Passenger door frame stop fitting is an important component to transfer loads from passenger door to airframe. The interfacial contact state between stop fitting and door stop greatly affects the load-carrying efficiency and structural reliability. In the interfacial contact process, there exists surface contact deviations from ideal design position between stop fitting and door stop. In order to evaluate the effect of contact deviation on load carrying capacity of door frame stop fitting, an automatic parametric analysis procedure was established by integrating ABAQUS and fatigue analysis tool based on Isight platform. By quantifying stochastic variable with probability distribution model, Monte Carlo sampling method was adopted to obtain random value of different variables, forming a parameterized automatic analysis process. Through many cyclic sampling and simulation analysis, stress/fatigue life principle was used to analyze static and fatigue strength reliability of stop fitting by considering in-plane surface contact deviation. The results show that the reliability of stop fitting's static and fatigue strength is more than 99.73% provided by 3σ principle within the scope of allowable deviation tolerance, which validates the reasonable dimension design of stop fitting, and this automatic parametric procedure can provide guidance for reliability analysis of other airframe structure.