Compared with general airliner operation, flight test has to face complex aircraft configuration, more critical flight condition, unusual flight envelop and maneuver, meanwhile specific test resources are available. The application of crew resource management(CRM) methods in flight test is helpful for both test safety and efficiency. This article compares the airliner operation and test flight activities, analyzes the characteristics of test flight resources from human resource, on-board equipment, procedure, telemetry and ground support resources. We analyzed CRM elements in test flights from the perspectives of situational awareness, communication, and decision-making, and studied the application of CRM methods in test flights. Taking the flight test subjects of flutter and engine control characteristics as an example, this paper explains how to apply CRM elements such as personnel configuration, telemetry, crew coordination and communication protocol in flight test implementation. The actual flight test experience shows that CRM can effectively enhance crew communication and collaboration, help optimize flight test resource allocation and reduce flight test risk and cost.