The total atmospheric pressure and static pressure in the environment of civil aircraft are measured by airborne air data sensors, and the airspeed can be calculated. In order to investigate aerodynamic characteristics of the total pressure probe layout location of civil aircraft, the flow field near the nose under different angles of attack and sideslip angles was obtained by CFD numerical calculation. Total pressure loss and airspeed error under different working conditions can be derived from local flow direction located on total-pressure probe and total pressure coefficient distribution. Results show that the layout position at which the local flow angle distribution curves are flat and compact is optimal for total pressure probe, and the local flow angle is insensitive to the angles of attack and sideslip. The yaw and pitch characteristics of the aircraft comes to an optimal solution. The prediction method in this paper works well in terms of effectiveness and accuracy, and the prediction accuracy agrees well with the total pressure probe measurement requirement. The airspeed error can be calculated correctly. Angle envelope of sideslip and attack should be considered when analyzing aerodynamic layout position of total pressure probe.