With the rapid development of science and technology, China’s civil aircraft industry has ushered in a golden period of development. In order to study the pylon characteristics of the largescale civil aircraft, taking the power plant and wing layout of a civil aircraft as the limiting condition, the effects of the two configurations on the aircraft pylon and wing were studied. Statically determinate pylon transferring load paths are clear and load path can not change when any connection structure damages. Statically indeterminate pylon transferring load paths are not clear and the same direction load are transferred by many connection structures, especially, the load paths will be changed when one connection structure damages, and the loads will be redistributed. By FEM analysis, it is found that the interface force of statically indeterminate pylon is larger than that of static pylon at the interface of pylon and wing which has a greater impact on the local design of wing. By comparing loads transfer and interface forces analysis of the two connection mode, this paper provides a reference for the design and development of large civil aircraft in China.