Fire is an important factor to affect the safe operation of transportation aircraft. As an emergency system of aircraft, The fire protection system can detect, monitor and alarm the designated protection area of the aircraft and provide effective fire fighting to ensure the safety of the aircraft and the personnel on board. Therefore, fire protection system is closely related to the flight safety of civil aircraft, and is also the content of airworthiness requirements. The purpose is to provide reference for airworthiness certification personnel on civil aircraft development and provide corresponding technical support for airworthiness certification of fire protection system. Based on the analysis of the functional requirements and design architecture of civil aircraft fire protection system, and in accordance with the requirements of CCAR 25, the corresponding acceptable compliance methods of aircraft fire protection system and the acceptable criteria in the verification test of fire protection system were analyzed. And the technical cross-linking and work coordination of the fire protection system in the airworthiness review were given. In view of the various clauses involved in the fire protection system, the certification elements and requirements for airworthiness review were provided for CAAC. The research is helpful to support the safety design and airworthiness verification of civil aircraft fire protection system.