In order to meet the multi-objective comprehensive optimal design goal of advanced high lift device for modern large aircraft, this paper combines the concurrent design idea of aerodynamics and mechanism, and builds the comprehensive design software of aerodynamics and mechanism of high lift device based on VB, QT and CATIA secondary development environment. It includes four design modules: wing body assembly, cruise configuration, take-off and landing configuration, mechanism design. Users can draw and combine the data points of different wing body sections to form the clean configuration designed by users. The NURBS curve is used to make the clean configuration quickly cut the curved surface shape with high lift device. According to the empirical values of gap parameters and mechanism constraints, the cutting high lift device is deflected and the appropriate take-off and landing positioning models are designed, and the corresponding positioning design mechanism is matched. This paper designs multi category large commercial aircraft, and according to the expected design, complete the cutting of different fixed wing models and wing body combination models. Verified by a large number of design examples, the software has a wide range of versatility, and can realize the rapid design of any aircraft lift device.