In cargo door surrounding frame assembly for Passenger to Freighter（PTF）, the lower main sill is parallel with the floor and lower than floor beam. It needs to design the fittings on the latch hook fitting to support the cross beam of floor panel, or the latch hook fitting supports the cross beam of floor panel directly. The latch hook fitting supporting the cross beam of floor panel is complicated, influenced by the cutframe at the frame station. Referring to the latch hooks design of Boeing and Airbus mature aircraft cargo bay，this paper analyzes and compares the latch hooks design in assembly, mechanical characteristics, manufacturing process, damage tolerance and so on. Considering the special layout of the cargo door surrounding frame assembly for PTF, this paper makes a design of the latch hook configuration and its interface. Its goal is to provide a design idea for the latch hook configuration for cargo door surrounding frame assembly for PTF.