For the fuselage with the wing center section of a civil aircraft, the effects of water entry speed, pitch angle and upswept angle upon the pressure distribution on the fuselage and the impact force during the water entry process are investigated numerically. In the numerical simulation, the unsteady compressible Reynoldsaveraged NavierStokes (RANS) equations and the realizable kε turbulence model are solved; the volumeoffluid method is used to capture the waterair interface; the global moving mesh method is used to deal with the relative motion between the fuselage and the water. The results show that, the peak pressure firstly occurs on the spray root in the water entry process of the fuselage, and then shifts to the bottom of the fuselage. The coefficient of impact force increases sharply in the initial stage of water entry, and then deceases slightly. In the late stage, the wing center section impact on the water surface can once again result in sharp increase of impact force coefficient, and then change slightly. Larger impact speed, larger pitch angle and smaller upswept angle leads to smaller impact force coefficient on the fuselage.