The Federal Aviation Administration William J. Hughes Technical Center has researched the environment friendly fire suppression system in aircraft cargo compartment for decades. This paper is based on the research and unscrambles the minimum performance standard for aircraft cargo compartment halon replacement fire suppression and extinguishing systems,which is developed by international aircraft system fire protection working group. This paper also summaries the latest research results of three fire extinguishing systems in aircraft that are nitrogen extinguishing system, aerosol fire extinguishing system and water mist fire extinguishing system. With an analysis on the current trend of the replacements of halon fire suppression and extinguishing system in large scale civil aircraft cargo compartment, it analyzes the feasibilities that if the three fire extinguishing systems are suitable for aircraft cargo compartment. This paper is aimed at providing reference for engineering technology of the replacements of halon fire suppression and extinguishing system in large scale civil aircraft cargo compartment.