Electrical wiring interconnection system (EWIS) as a part of FAR 25 regulation is issued in the end of 2007, which requires EWIS shall be considered as an important integrated system of aircraft, and EWIS development shall comply with systematic methods. EWIS configuration management (CM) is an essential part for certification. This paper introduces the features of EWIS development accompanied with the challenges for EWIS configuration management. The objects and key contents of EWIS configuration management are analyzed and studied. The strategy methods are presented. This paper can be very helpful to guide EWIS development for civil aircraft.