This paper carries out detailed analysis and research of several hotspots in the implementation of design assurance system for civil aircraft manufacturers, which include the current status of domestic industry airworthiness and design assurance, how to carry out independent monitoring of design assurance system, the continued airworthiness requirements of design assurance system, the relationship between DAS and QMS, etc. The research provides beneficial reference and proposals of the establishment and implementation of design assurance system and independent monitoring based on the current airworthiness management basis for domestic civil aircraft manufacturer.