In this paper, simulation analysis and experimental validation are applied for indicating air distribution configuration complied with the requirements. Firstly, the cabin/cockpit heat load dynamic model is set up and air supply requirement is analyzed. Secondly, to fulfill the target of air supply, Flowmaster model for one civil aircraft air distribution system is built and quantity of supplied air is adjusted based on the model. Lastly, ground/flight test is performed to validate simulation result similar with test result, and the air supplied to the cabin and cockpit meets the requirement of air worthiness standard and high level requirement. This attempt is the trial of civil aircraft air conditioning system distribution development and research, and the methods adopted are effectively enhancing the civil aircraft independent research capability.